Whole genome methylation profiling in HepG2 cells using WGBS (Whole Genome Bisulfite Sequencing)

We performed WGBS analysis of HepG2 cells using ENCODE Consortium Data to study CpG methylation and their association with TFBS (transcription factor binding sites). WGBS data was produced by ENCODE Production Lab and submitted to ENCODE Data Coordination Center. We further processed the data to generate whole genome methylation profile using Bismark and Bowtie2 aligner. An alternative analysis of ENCODE data.