USP5 Zf-UBD Co-Crystal Structure with Compound XSR00035795a & Testing Selectivity
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Growth of well-diffracting co-crystals of USP5 zinc finger ubiquitin binding domain (Zf-UBD) and compound XSR00035795a to solve the structure to determine ligand interactions in the binding pocket. A surface plasmon resonance assay was used to determine if methyl group on carboxylic chain of compound XSR00035795a confers selectivity to USP5 versus HDAC6.
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Zenodo创建时间:
2019-03-01



