Exercise intervention on serum insulin-like growth factor-1 in elderly patients with sarcopenia and frailty

Senile sarcopenia and frailty are important public health issues in an aging society, characterized by decreased muscle mass, strength, and function, closely related to decreased serum IGF-1 levels. IGF-1, as a key regulatory factor in muscle synthesis metabolism, may improve muscle function when its level is elevated. Current research suggests that exercise intervention can regulate IGF-1, but the results are highly heterogeneous and lack systematic evaluation. This study integrates evidence through meta-analysis to provide reference for optimizing exercise prescriptions.