Pharmacokinetic parameter of oxycodone and its metabolites.

Abbreviations: Cmax, peak plasma concentration; Tmax, time to peak plasma concentration; AUC0→8, area under the time-concentration curve from 0 to 8 hours; ratio, the ratio of the geometric mean value of CR oxycodone with aprepitant to those without aprepitant.Geometric mean (% coefficient variance).Values were corrected for dose, assuming that all patients received 20 mg of oxycodone.*Paired t-test for difference between logarithmic geometric means (two-sided).**Five patients were excluded due to below lower limit of quantitation.