Palladium-Catalyzed C–N Bond Cleavage of 2H‑Azirines for the Synthesis of Functionalized α‑Amido Ketones
收藏Figshare2019-02-01 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Palladium-Catalyzed_C_N_Bond_Cleavage_of_2_i_H_i_Azirines_for_the_Synthesis_of_Functionalized_Amido_Ketones/7660676
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资源简介：
A Pd-catalyzed ring-opening reaction of 2H-azirines with carboxylic acids was developed. This reaction undergoes nucleophilic addition between 2,3-diaryl-2H-azirines and carboxylic acids followed by C–N single-bond cleavage and a subsequent thermal rearrangement. This method enables the rapid construction of valuable α-amido ketone derivatives with high atomic efficiency and superb functional group tolerance.
创建时间：
2019-02-01
