Gut microbiome communication with the bone marrow regulates intestinal inflammation and susceptibility to amebiasis.. Gut microbiome communication with the bone marrow regulates intestinal inflammation and susceptibility to amebiasis.

We discovered that colonization of the gut with the human bile acid 7'-dehydroxylating bacteria Clostridia scindens provided immunity to the parasite E. histolytica in a murine model, increased granulocyte monocyte progenitors, and that adoptive marrow transplant from C. scindens colonized mice into naive mice could recapitualte this protection. Overall design: RNA-seq in granulocyte monocyte progenitors