Knockdown of hsa_circ_0008922 inhibits the progression of glioma

Background: we preliminarily outlined the expression of hsa_circ_0008922 in glioma and explored its biological functions. Methods:with RNA sequencing of a panel of glioma tissues and normal brain tissues, The 10 tissues were divided into two groups:C (normal brain tissue, n = 5) and T (tumor tissue, n = 5). With the hsa_circ_0008922 downregulated cells, a series of assays were carried out as follows. Results:We found that the expression of hsa_circ_0008922 in glioma tissues was 3.4 times higher than that in normal tissues. And the expression of has_circ_0008922 was correlated with WHO tumor grade. After down-regulating the expression of hsa_circ_0008922, malignant biological behavior of glioma cells was inhibited, such as cell proliferation, colony formation, migration, and invasion. with RNA sequencing of a panel of glioma tissues and normal brain tissues, The 10 tissues were divided into two groups:C (normal brain tissue, n = 5) and T (tumor tissue, n = 5). With the hsa_circ_0008922 downregulated cells