FC PIK3ca* mice baseline characteristics and tolerability of rapamycin versus placebo.

Twenty-two mice at 55 days of age were randomized 1∶1 to rapamycin or placebo treatment arms. Mice were stratified based on gender and pretreatment tumor size. These mice tolerated the treatment well as demonstrated by minimal change in weight from baseline. In the placebo cohort, two mice became moribund prior to study completion. In both instances, large proximal colon tumors caused obstructive enteropathy. All mice in the rapamycin treated cohort completed the treatment course as intended. Tx, treatment.