Fetal and trophoblast PI3K p110α have distinct roles in regulating resource supply to the growing fetus. Fetal and trophoblast PI3K p110α have distinct roles in regulating resource supply to the growing fetus

Using RNA-seq we identified several genes downstream of p110α in the trophoblast that are important in adapting placental phenotype to support fetal growth. Overall design: This was achieved by comparing the transcriptomes of 5 Het-U (heterozygous deficient in p110α in both fetal and trophoblast lineages) and 4 Hom-P (heterozygous deficient in p110α in fetal lineage and homozygous deficient in p110α in trophoblast) placentas placentas at day 19 of pregnancy.