Comparison of Hematologic and Organ Function Parameters at Enrollment and Last visits in Patients with HbSS Based on Hydroxyurea Status and Fetal Hemoglobin Quartile.

Abbreviations: HU, hydroxyurea; Low HbF, maximum fetal hemoglobin within the lowest quartile; High HbF, maximum fetal hemoglobin within the highest quartile; ANC, absolute neutrophil count; MCV, mean corpuscular volume; ARC, absolute reticulocyte count; ALT, alanine aminotransferase; AST, aspartate aminotransferase; TRV, tricuspid regurgitant velocity; NT-ProBNP, brain natriuretic peptideaConversion factor from U/L to μkat/L is 0.017; conversion factor from mg/dL to μmoL/L is 17.1bWilcoxon rank-sum test, other p-values are from t-tests if not otherwise specifiedcEjection fraction and TRV were reported in 345 subjects at first visit and 261 subjects at last visitdNT-ProBNP levels are only reported in patients with a creatinine #p##p###p*p**p***pComparison of Hematologic and Organ Function Parameters at Enrollment and Last visits in Patients with HbSS Based on Hydroxyurea Status and Fetal Hemoglobin Quartile.