Epidermal Growth Factor Receptor Activation is Essential for Kidney Fibrosis Development
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https://www.ncbi.nlm.nih.gov/sra/SRP464973
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We found that EGFR expression increased in interstitial myofibroblasts in human and mouse fibrotic kidneys. Selective EGFR deletion in the fibroblast/pericyte population inhibited interstitial fibrosis in response to unilateral ureteral obstruction, ischemia or nephrotoxins. We used single-nucleus RNA sequencing analysis to demonstrate the role of EGFR activation in UUO model. Overall design: Kidneys from both WT mice and FibEGFR-/- mice at day 1 and day 3 after UUO were used with kidneys of 3-5 mice from same group being combined for analysis.
创建时间：
2024-02-02
