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Targeting Bowel Tissue for Drug Delivery System by Human and Mouse GPA33 Cross-Reactive Fully Human Antibody

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NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/sra/DRP012232
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In this study, we aim to isolate and characterize a fully human anti-GPA33 antibody by combining phage display technology with trans-chromosomic animals. The isolated antibodies showed high specificity and affinity for GPA33 and, more importantly, cross-reactivity to both human and mouse GPA33 antigen. This cross-reactivity increases the utility of the antibody in preclinical models and may more accurately predict therapeutic efficacy in humans.
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2024-11-15
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