Association between TLR4 haplotypes and LOAD.

Abbreviations: LOAD, late-onset Alzheimer's disease; AOR, adjusted odds ratio; CI, confidence interval; DM, diabetes mellitus; HAP, haplotype; NA, not applicable; SNP, single nucleotide polymorphism; ApoE e4, apolipoprotein E e4.All models were adjusted for age, gender, education, and ApoE e4 status.Minor alleles were underlined.Numbers in bold indicates statistically significant findings (pa0 copies, wild type; 1 copy, heterozygotes; 2 copies, homozygous variants.*The result remained significant (2 copies of HAP1, p = 0.003) after controlling for type I error by using Bonferroni correction (α = 0.05/4).