Molecular inversion probe based sequencing of Peruvian Plasmodium vivax

This study uses novel molecular inversion probe (MIP) panels to sequence Plasmodium vivax samples from the Peruvian Amazon. Each sample is captured and sequenced with four separate MIP panels: 1) PvG - a tiled gene panel targeting putative antimalarial resistance genes and blood-stage vaccine targets; 2) PvFST - a panel targeting 400 geographically discriminating SNPs detected during a global Pv variant calling analysis, as well as SNPs from other published panels; 3) PvMAF5 - a panel targeting 400 neutral low-frequency SNPs (minor allele frequency = 0.05); and 4) PvMAF40 - a panel targeting 400 neutral high-frequency SNPs (minor allele frequency = 0.4).