Dysregulation of host gene expression by mouse papillomavirus type 1 (MmuPV1) infection

We performed comprehensive analysis of host gene expression in MmuPV1 infected ear tissues with tumor (T) or without (I) visible warts. The ear tissues from mock-infected (control, C) animals were used as negative control. Total RNA from the collected tissues of 3 animals from each group was subjected to Illumina RNA-seq. After mapping to mouse genome, the genes with dysregulated expression in infected or tumor samples were identified based on comparison to mock-infected contol samples. Gene expression profiling of ear tissues from athymic BALB/c Fox1 nu/nu mice with MmuPV1 or mock infection using Illumina total RNA-seq.