Comparison of HCC cell lines and primary HCCs-RNAseq data

There are concerns about whether cancer cell lines could faithfully represent the matched primary cancer cells. Comparison of the HCC cell lines and primary HCCs demonstrated that, during long-term in vitro culture, cell lines retain the genetic landscape of the matched primary HCCs. Overall design: RNAseq and WGS comparison of of 9 matched primary HCCs, early-passage PDCs and late-passage cell lines.