Whole kidneys at embryonic day 17.5: wildtype (WT) vs. various combinations of the conditional homozygous Ezh2-knockout (Ezh2-KO) from Six2-positive nephron progenitor cells (NPC) and/or germline Ezh1-knockout (Ezh1-KO)

Transcriptional profiling of whole kidneys from Six2CreEGFP mice without (WT) or with (KO) homozygously floxed Ezh2 alleles at the age of embryonic day 17.5. This experiment aimed to uncover the genome-wide alternation in gene expression resulting from the removal of Ezh2 gene in the nephron progenitor population (Six2 positive) in combination with the removal of Ezh1 gene from germline, and successive changes to the series of events in kidney development. Two-condition experiment, WT vs. KO kidneys. Biological replicates: 4 for each of 4 different genotypes