Systems approach identifies HIPK2 as a critical regulator of kidney tubulointerstitial fibrosis

ChEBI2012-02-01 更新2026-07-21 收录

纤维化机制

疾病靶点发现

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-35226 数据链接链接失效反馈

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Systems approach identifies HIPK2 as a critical regulator of kidney tubulointerstitial fibrosis

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2012-02-01

Interleukin-1 contributes to clonal expansion and progression of bone marrow fibrosis in JAK2V617F-induced myeloproliferative neoplasm

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JAK2V617F突变MPN

The somatic JAK2V617F mutation is found in a majority of patients with myeloproliferative neoplasms (MPN). Chronic inflammation is often associated with MPN, but the role of inflammation in the pathog

NIAID Data Ecosystem50

Gene expression analysis of mouse liver after bile duct ligation (BDL) treated or not with anti-miR-873

纤维化机制

miRNA调控

Background & Aims. Glycine N-methyltransferase (GNMT) is an essential regulator of the total transmethylation flux in the mammalian liver. Distinct DNA methylation patterns are characteristic of liver

NIAID Data Ecosystem30

Top ranked drugs and targets for therapy related to FOXA1 status, based on Connectivity Map

药物重定位

疾病靶点发现

†Function as described Martindale monograph. *Function as described in ChemBank (http://chembank.broadinstitute.org/). Na number of instances in which the compounds were tested in Connectivity map. Pb

NIAID Data Ecosystem20

Data_Sheet_1_Pyruvate kinase M2 modification by a lipid peroxidation byproduct acrolein contributes to kidney fibrosis.docx

纤维化机制

糖尿病发病机制

Renal fibrosis is a hallmark of diabetic nephropathy (DN) and is characterized by an epithelial-to-mesenchymal transition (EMT) program and aberrant glycolysis. The underlying mechanisms of renal fibr

NIAID Data Ecosystem40

Different effects of rat interferon alpha, beta and gamma on rat hepatic stellate cell proliferation and activation

纤维化机制

干扰素反应

BACKGROUND: Liver fibrosis is the common sequel of chronic liver diseases. Recent studies have identified hepatic stellate cells as the primary cell type mediating hepatic fibrogenesis. It has been de

PubMed Central2002-04-08 更新20

Systems approach identifies HIPK2 as a critical regulator of kidney tubulointerstitial fibrosis

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