Characterization of variants in known genes conferring Bedaquiline (BDQ) resistance and efflux pumps in BDQ naive pre-XDR/XDR MTB isolates using whole genome sequencing

To study resistance associated variants (RAVs) in Bedaquiline (BDQ) naive population of M/XDR MTB isolates from Pakistan using whole genome sequencing to simultaneously identify :(I) RAVs in the known genes contributing to BDQ resistance,(II) to identify presence if any of unique Single Nucleotide Polymorphism (SNPs) in MTB known efflux pumps associated with drug resistance in our BDQ R M/XDR MTB isolates.