Two known loci with significant age-difference in genetic effects on late stage AMD.

Shown are the genome-wide significant (PAgediff < 5 x 10−8) lead variant at the CFH locus and two of the 34 known variants from Fritsche et al [13], which revealed significant age-dependency (PAgediff < 0.05/34, corrected for 34 known lead variants from Fritsche et al). Age-stratified analyses included 17,031 younger (7,959 cases, 9,072 controls) and 16,587 older (7,934 cases, 8,653 controls) individuals.