Figure 4 | Inoculation of aSyn PFF-2, but not PFF-1, induce motor deficits within 16 weeks

(A) Schematic of the forelimb grip force test, used to measure muscle strength. Subjects grasped a smooth, triangular pull bar with both forelimbs and the force exerted in Newtons (N) was measured. (B) aSyn PFF-2 but not PFF-1 inoculated mice displayed a significant reduction in forelimb muscle strength at 16 weeks post injection (WPI) relative to 8 (2-way RM ANOVA, Group x Session: main effect of group (F2,72= 4.409, p0.05). A significant interaction was first observed, (F18, 675= 1.767, p0.05)). However, (E) aSyn PFF-2 mice exhibited a shorter latency to fall at 16 WPI relative to aSyn PFF-1 and PBS controls (2-way RM ANOVA, Group x Session: Main effect of group (F2,71= 7.436, p0.05). To examine this main effect further, Šídák's multiple comparisons revealed a significant difference between aSyn PFF-2 and PBS controls (adj. p0.05), but a main effect of session (F1,24= 4.493, p0.05), but a main effect of session (F1,24= 6.537, p0.05), but a main effect of session (F1,24= 9.232, p