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A phase I study of irinotecan, bevacizumab and biweekly TAS-102 in Japanese patients with metastatic colorectal cancer refractory to fluoropyrimidine and oxaliplatin

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NIAID Data Ecosystem2026-03-09 收录
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Interventions: TAS-102 25-35 (mg/m2) day1-5 CPT-11 150-180 (mg/m2) day 1 Bevacizumab 5 (mg/kg) day 1 every 2 weeks Primary outcome(s): Part1(dose-escalation): DLT between first 2 cycles Part2(expansion): the incidence of febrile neutropenia Study Design: Single arm Non-randomized

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2016-09-15
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