Estimated in vivo % residual DNA-dependent polymerization for distinct mutants and drug combinations.
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In vivo concentration ranges were 3TC-TP = 12.2–40.5; FTC-TP = 1.5–19.4; TFV-DP = 0.16–1.17; CBV-TP = 0.44–0.88; d4T-TP = 0.034–0.56; and AZT-TP = 0.0056–0.056 respectively [56], [71], [73]–[75], assuming an average cell volume of for resting T-cells [72].
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2015-12-02
