Impact of Thalamic Stimulation on somatomotor cortical areas and striatum in deeply anesthesized mice (v1)

Recent theoretical advances describing brain states from information and integration have highlighted the unique role of the thalamocortical system in leading to integrated information and thus, consciousness. Although interactions between the thalamus, striatum, and cortex are critical for cognitive function, the exact contribution of the thalamus to these interactions remains unclear. Manipulating neural activity and brain states is of significant therapeutic interest in several neurological disorders and can be achieved by electrical stimulation. In this context, this dataset provides a characterization of the impact of thalamic electrical stimulation on the cortical and striatal activity in deeply anesthetized mice. For that, we electrically stimulated ventral posteromedial thalamic nucleus to analyze the spontaneous slow oscillation activity and the evoked responses in the striatum and cortex. These results open the way to study the role of the thalamus in the spatiotemporal patterns of activity of brain states, their transitions, and their links to cognition and behavior.