Data Set on the effect of oleic acid on the Reproductive Immuno-endocrine Regulation of Female Wistar Rats on an Unrestricted Diet

We sought to ascertain if oleic acid, when administered to female Wistar rats on an uncontrolled or unrestricted diet, could alter the levels of immune white blood cells and reproductive endocrine indices. The data were obtained from female Wistar rats (n=18, 10- 12 weeks old, 151 ± 24 g) on an unrestricted diet and treated with different oleic acid doses. The effect of oleic acid (364525-IL Sigma-Aldrich, USA) at 0, 500 and 1000 mg/kg body weight was investigated on the full-blood count (WBC and RBC parameters), and reproductive endocrine indices (reproductive hormones, reproductive organ weights and oestrous cyclicity) of female Wistar rats treated for three cycles (15 days). The results indicated that oleic acid treatment induced increased body weight gain and relative reproductive tract weight in the rats. However, it did not affect Wistar rats reproductive hormone levels, oestrous cycle and RBC parameters. Notably, oleic acid altered the white blood cell parameters in the rats, specifically reducing the lymphocyte population of white blood cells and increasing the Mid- cells (Basophils, eosinophils, monocytes, and mast cells) and neutrophils.
[Data 1] Body weights of the female Wistar rats before treatment commenced, and after treatment, and the increases in body weights were measured and presented.
[Data 2] The organ weights (paired ovaries and reproductive tract) were presented relative to the body weights as g/100 g body weight.
[Data 3] The rats were classified into four oestrous stages; proestrus, oestrus, metoestrus, and dioestrus. The stages were assigned numbers 1, 2, 3, and 4, respectively.
[Data 4] The blood of five rats from each group was analyzed for its full blood count (Red blood cells, white blood cells, and plateletes).
[Data 5] The rat's serum was analyzed for oestrogen, progesterone, and LH levels.