Heparanase is the sole mammalian enzyme capable of cleaving glycosaminoglycan heparan sulfate side chains of heparan sulfate proteoglycans. Its altered activity is intimately associated with tumor gro
6-Diazo-5-oxo-l-norleucine (DON) is a glutamine antagonist with robust anticancer efficacy; however, its therapeutic potential was hampered by its biodistribution and toxicity to normal tissues, speci
Retrofitting antibodies with stabilizing mutations. Herceptin scFv mutant. Descriptor: Human Variable Heavy Chain of Herceptin, Human Variable Light Chain of Herceptin Authors: Langley, D.B, Roome, B,
The deadliest anaplastic thyroid cancer (ATC) often transforms from indolent differentiated thyroid cancer (DTC), however the complex intra-tumor transformation process is poorly understood. We inves
