Supplementary data_ H reflex dynamics in Preterm Infants

Background: Proximal nerve maturation in preterm infants and its resilience to physiological stress remain understudied. This study aimed to determine the maturation dynamics of proximal nerve conduction using the H-reflex, evaluate the impact of early respiratory distress, and explore its predictive value for long-term neuro-motor outcomes. Methods: A prospective longitudinal study was conducted on 63 infants (56 preterm, 28–36 weeks; 7 term controls). Serial H-reflex examinations (n=104) were performed from birth until discharge. Maturation of H-reflex latency (HRL) and conduction velocity (HRCV) was analysed against post-menstrual age (PMA). Multivariate regression assessed the impact of Early Respiratory Distress (ERD) on nerve conduction. A 5-year follow-up evaluated neuro-motor status using the INDT-NMI tool. Results: HRCV increased linearly with PMA (p