Data Base: Data included: individual methylation values per CpG site, clinical and sociodemographic variables

This dataset supports the study "Differential methylation of <i>SNCA</i> and <i>MAPT</i> genes associated with Parkinson’s disease in Mexican Mestizos", published in <i>Frontiers in Aging Neuroscience</i>. The case-control study included 108 patients with Parkinson’s disease (PD) and 108 matched controls of Mexican Mestizo ancestry. DNA methylation levels at specific CpG sites within the promoter region of <i>MAPT</i> and intron 1 of <i>SNCA</i> were measured using bisulfite pyrosequencing.Significant global and site-specific hypomethylation was found in PD patients compared to controls. Stratified analyses revealed region-specific (northern and central Mexico) and sex-specific methylation differences: <i>MAPT</i> hypomethylation was prominent in men, while <i>SNCA</i> hypomethylation was significant in women. Logistic regression confirmed the association of <i>MAPT</i> and <i>SNCA</i> methylation with PD risk, suggesting these epigenetic changes may serve as peripheral biomarkers in a population-specific context.