Koivumaki2009_SERCAATPase_long

This a model from the article:
Modelling sarcoplasmic reticulum calcium ATPase and its regulation in cardiac
myocytes.

Koivumaki JT, Takalo J, Korhonen T, Tavi P, Weckstrom M. Philos Transact A Math Phys Eng Sci
2009 Jun 13;367(1896):2181-202 19414452
,
Abstract:

When developing large-scale mathematical models of physiology, some reduction in
complexity is necessarily required to maintain computational efficiency. A prime
example of such an intricate cell is the cardiac myocyte. For the predictive
power of the cardiomyocyte models, it is vital to accurately describe the
calcium transport mechanisms, since they essentially link the electrical
activation to contractility. The removal of calcium from the cytoplasm takes
place mainly by the Na(+)/Ca(2+) exchanger, and the sarcoplasmic reticulum
Ca(2+) ATPase (SERCA). In the present study, we review the properties of SERCA,
its frequency-dependent and beta-adrenergic regulation, and the approaches of
mathematical modelling that have been used to investigate its function.
Furthermore, we present novel theoretical considerations that might prove useful
for the elucidation of the role of SERCA in cardiac function, achieving a
reduction in model complexity, but at the same time retaining the central
aspects of its function. Our results indicate that to faithfully predict the
physiological properties of SERCA, we should take into account the
calcium-buffering effect and reversible function of the pump. This
'uncomplicated' modelling approach could be useful to other similar transport
mechanisms as well.
This model was taken from the CellML repository
and automatically converted to SBML.
The original model was:
Koivumaki JT, Takalo J, Korhonen T, Tavi P, Weckstrom M. (2009) - version=1.0

The original CellML model was created by:
Geoffrey Nunns

[e-mail]
The University of Auckland
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