Metadata record for the manuscript: SOX4 and SMARCA4 cooperatively regulate PI3K signaling through transcriptional activation of TGFBR2

Summary This metadata record provides details of the data supporting the claims of the related manuscript: “SOX4 and SMARCA4 cooperatively regulate PI3K signaling through transcriptional activation of TGFBR2”. The related study aimed to demonstrate that the transcription factor SOX4 is a key regulator of PI3K signalling in triple-negative breast cancers (TNBCs). Type of data: RNA sequencing data (n=1,031) from human tumors; Illumina HT-29 v3 expression data for the METABRIC (Molecular Taxonomy of Breast Cancer International Consortium) project (n=1,992) Subject of data: human breast tumors and breast cancer cell lines Data access RNAseq data have been deposited in the Gene Expression Omnibus (GEO) under accession number https://identifiers.org/geo:GSE158295. Proteomic data from MIB/MS (https://identifiers.org/pride.project:PXD022596) and IP-MS (https://identifiers.org/pride.project:PXD022811) analyses have been made available through the PRIDE database. SMARCA4 (https://identifiers.org/geo:GSE72141), H3K27ac and H3K4me3 (https://identifiers.org/geo:GSE85158) ChIP-Seq raw data from MDA-MB-231 cells were acquired from Gene Expression Omnibus (GEO). The data for Figures 1, 2, and 5 are presented in supplemental Tables S1, S2, S3, S4, and S5, which are available in Excel format as part of this metadata record, as well as in PDF format via the supplementary materials of the related article. Corresponding author(s) for this study Michael L. Gatza, Ph.D., Rutgers Cancer Institute of New Jersey, 195 Little Albany Street CINJ 4558, New Brunswick NJ 08903, Ph: 732-235-8751, [e-mail]