Integrated DNA methylation datasets (Illumina EPIC) from septic, septic shock, PICS and non‑PICS patients – GEO datasets (GSE319925, GSE247524, GSE285813)

The project encompasses three GEO datasets, containing human blood simples analysed with Illumina Infinium MethylationEPIC arrays. The datasets consist of raw .idat files and processed data files containing beta values, as well as metadata files describing each sample. All samples come from septic patients and controls. 1) GSE247524 (public)Dataset associated with the publication in Frontiers in Immunology (2024) by Beltrán‑García et al.Includes methylation data from leukocytes of septic patients with severe clinical phenotypes and immunosuppression.Publication:Beltrán‑García J. et al., 2024. Front Immunol. 14:1333705. DOI: 10.3389/fimmu.2023.1333705.GEO Accession: GSE247524. 2) GSE285813 (public)Dataset associated with the 2025 study in Frontiers in Cellular and Infection Microbiology by López‑Cruz et al.Compares methylation profiles of septic vs. non‑septic patients with similar infectious conditions, exploring their utility as biomarkers.Publication:López‑Cruz I. et al., 2025. Front Cell Infect Microbiol. 14:1532417. DOI: 10.3389/fcimb.2024.1532417.GEO Accession: GSE285813. 3) GSE319925 (private) Contains raw .idat files generated with Illumina EPIC arrays.The dataset is private in GEO until the associated manuscript is published.