Spatiotemporal pathological alternations during syringomyelia formation and resolution [scRNA-seq]

Syringomyelia is a common clinical lesion associated with arachnoid adhesion, traumatic injury, intramedullary tumor, and congenital or acquired spinal deformities. However, the mechanism of syringomyelia formation and resolution remains controversial. We previously constructed a reversible rat model with extradural compression to closely reproduce the canalicular syringomyelia in the human condition. It is quite necessary to depict the spatiotemporal pathophysiological changes of syringomyelia more precisely by transcriptomic analyses during syrinx development and regression. The spinal cord tissue centered on the syringomyelia segments were collected for single-cell RNA sequencing at different time points after extradural compression in rat model.