Txn1 mutation is a monogenic cause of chronic kidney disease associated with mitochondrial dysfunction in rats

Oxidative stress plays a significant role in the progression of chronic kidney disease. Thioredoxin 1 (Txn1) is one of the enzymatic antioxidants to regulate redox balance. However, the molecular mechanisms by Txn1 affects renal homeostasis remain unclear. This study aimed at elucidating the pathophysiology of rats with Txn1-F54L mutation in renal function.