Summary of the changes in estimated EC₅₀ values for ATP and changes in desensitization at the DF and LF alanine/cysteine mutants of P2X1-4R residues from published data.

n. f., non-functional mutants; ↑ mutant with significant increased EC50 in comparison to WT (values represent fold increase); ≈ close to WT receptor; D, affected time-constant of the desensitizing current response; -, non-investigated position; n.i., non-investigated P2X4R mutants that were analyzed in this study. Summary of the changes in estimated EC50 values for ATP and changes in desensitization at the DF and LF alanine/cysteine mutants of P2X1-4R residues from published data.