Pleiotropy matrices for eGenes and eQTLs

The Phenotype eQTL overlap sheet has names of phenotypes in columns TraitX and TraitY. The number of eQTLs identified for TraitX and TraitY are given in eQTLsX and eQTLsY. The column, Common, is the number of eQTLsY that are in eQTLsX. Ratio is Common divided by eQTLsX.The Phenotype eGene overlap sheet has names of phenotypes in columns TraitX and TraitY. The number of eQTLs identified for TraitX and TraitY are given in eGenesX and eGenesY. The column, Common, is the number of eGenesY that are in eGenesX. Ratio is Common divided by eGenesX.In the Control eGene overlap sheet, all 7,917 eGenes were pooled together and randomly assigned to phenotypes so that each phenotype in the control matrix had the same number of eGenes as its corresponding phenotype in the eGene matrix. The pairwise ratios of common eGenes among the phenotypes were calculated as done in the eGene matrix. 1000 different null datasets were constructed in this manner and the mean matrix was calculated. The Ratio column is the mean of 1000 null sets between phenotypes in columns TraitX and TraitY.

该表型eQTL重叠表中，TraitX和TraitY列包含了表型的名称。在eQTLsX和eQTLsY列中给出了针对TraitX和TraitY识别出的eQTL数量。'Common'列表示存在于eQTLsX中的eQTLsY的数量。'Ratio'是指'Common'与eQTLsX之比。表型eGene重叠表中，TraitX和TraitY列同样包含表型的名称。在eGenesX和eGenesY列中提供了针对TraitX和TraitY识别出的eGene数量。'Common'列代表存在于eGenesX中的eGenesY的数量。'Ratio'是指'Common'与eGenesX之比。在控制eGene重叠表中，所有7,917个eGene被合并，并随机分配到各个表型中，以确保控制矩阵中每个表型对应的eGene数量与eGene矩阵中相应表型的eGene数量相同。计算了表型间常见eGene的双向比率，计算方法与eGene矩阵中相同。以此方式构建了1,000个不同的零样本数据集，并计算了平均矩阵。'Ratio'列是TraitX和TraitY列中表型间1,000个零样本集合的平均值。