Raw Data for manuscript (doi 10.3389 fnut.2022.1045805)
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Fructose promoted purine<em> de novo</em> synthesis to generate IMP and drive conversion of IMP to AMP to maintain the rapid depletion of ATP. Fructose increased the breakdown of preformed PNs and their derivatives (adenine, xanthine, and hypoxanthine), accelerated their degradation to UA, and increased the serum UA level. This work revealed that increased purine <em>de novo</em> synthesis may be a crucial mechanism in fructose-induced hyperuricemia.
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2022-12-09
