The receptor tyrosine kinase EphB2 promotes MASH fibrosis in mice.

Metabolic dysfunction-associated steatohepatitis (MASH) is emerging as the leading cause for liver transplantation worldwide. MASH is chatacterized by hepatic lipid accumulation, inlammation and fibrosis which is associaed with worst outcome in patients sufferring from this pathology. Using the Gubra Amyln NASH (GAN) diet model of murine MASH, we showed that global deletion of Ephb2 in mice protect them from GAN diet-induced inlammation and fibrosis. EphB2 could be a potential therapeutic target for the treatment of MASH fibrosis. Overall design: Six to eight weeks old male mice were fed the Gubra Amylin NASH (GAN)diet a high-fat diet (RESEARCH DIETS D09100310i containing 40% kcal fat (mostly palm oil), 20% kcal Fructose, and 2% Cholesterol) for 26 weeks.