Wild-type, Foxa2-/-, and Nkx2.2-/- mESCs at different time points of differentiation
收藏NIAID Data Ecosystem2026-03-13 收录
下载链接：
https://www.ncbi.nlm.nih.gov/sra/SRP348671
下载链接
链接失效反馈官方服务：
资源简介：
We report gene-expression profiling of different mouse embryonic stem cells (mESCs) mutant cell lines differentiating to neuronal lineages upon treatment with Retinoic Acid (RA) and Smoothened agonist (SAG). We generated genome-wide expression profiles of embryonic stem cells and neural progenitors at different differentiating time-points for different mutant cell lines and WT control mESCs. We find NKX2.2 and FOXA2 are key components of an intrinsic timer in neural stem cells founded on a negative feedback network that regulates the duration of motor neuron neurogenesis. Overall design: mRNA expression profiles of wild-type, Foxa2-/-, and Nkx2.2-/- mESCs at different time points of differentiation.
创建时间：
2022-03-04
