MHC genotyping of macaques against MHC Class Ι alleles.

Macaque samples were tested against a panel of nine MHC class Ι alleles that have previously been shown to be important in SIV epitope presentation or increased resistance to SIV infection [24],[25],[26]. The alleles are: Mamu-A*01, Mamu-A*02, Mamu-A*08, Mamu-A*11, Mamu-B*01, Mamu-B*03, Mamu-B*04, Mamu-B*08, and Mamu-B*17. Animal 90140 is positive for Mamu-A*01 and animal 95066 was determined to carry the Mamu-B*01 allele. Mamu-A*01 has been associated with moderate control of SIVmac239 replication [29],[30]. Mamu-B*01 remains on the panel based on early reports of SIV-derived epitopes [31],[32], but subsequent studies show that Mamu-B*01 does not bind SIV-derived epitopes and has no effect on SIV disease progression [26]. P, N, I, C denotes protected, non-protected, isotype control, and non-antibody treated control animals, respectively.