Organocatalytic Nonclassical Trienamine Activation in the Remote Alkylation of Furan Derivatives
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https://figshare.com/articles/dataset/Organocatalytic_Nonclassical_Trienamine_Activation_in_the_Remote_Alkylation_of_Furan_Derivatives/2107021
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资源简介：
A new approach for the stereoselective
remote alkylation of furan
derivatives is reported. The reaction of 5-alkylfurfurals with nitroolefins
as electrophilic counterparts occurs at their exocyclic ε-position
and proceeds through the intermediacy of a nonclassical catalytic
trienamine intermediate. The aminocatalyst bearing a H-bonding unit
is used to control the stereochemical reaction outcome confirming
the usefulness of such catalytic systems for the remote functionalizations
of carbonyl compounds. Target products with two adjacent stereogenic
centers are obtained in excellent yields and with good to moderate
stereoselectivities.
创建时间：
2016-02-12
