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Metal-Free Coupling of 2‑Vinylphenols and Carboxylic Acids: An Access to 3‑Acyloxy-2,3-dihydrobenzofurans

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NIAID Data Ecosystem2026-03-09 收录
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https://figshare.com/articles/dataset/Metal_Free_Coupling_of_2_Vinylphenols_and_Carboxylic_Acids_An_Access_to_3_Acyloxy_2_3_dihydrobenzofurans/2111938
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资源简介:
A new coupling reaction between 2-vinylphenols and carboxylic acids was developed to synthesize 3-acyloxy-2,3-dihydrobenzofurans using Bu4NI as a catalyst and t-BuOOH as an oxidant. This simple and practical methodology is notable due to the ability to complete it under metal-free conditions, with easily available precursors, resulting in a product with high atom economy and high functional group tolerance. Upon the basis of experimental observations and literature, a plausible mechanism is proposed.
创建时间:
2016-02-12
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