Smart Nanoparticles for Diagnosis and Therapy of Atherosclerosis

This thesis develops and evaluates smart nanoparticles for imaging and treating cardiovascular diseases, particularly atherosclerosis and thrombosis. It presents two main studies. First, fluorine-doped iron oxide nanoparticles enhance magnetic particle imaging with better sensitivity and biocompatibility. Second, two types of therapeutic nanoparticles are explored: VCAM-1-targeted liposomes delivering cyclodextrin and ROS-responsive polymer micelles. Both systems show selective targeting and anti-inflammatory effects respectively along with improved cholesterol clearance in cell-based models. These results indicate strong therapeutic promise. The nanoparticles offer safer, more effective strategies than existing treatments. This work holds practical value for advancing non-invasive imaging and targeted therapy in atherosclerosis management.