Sachse2008_FibroblastInteractingMyocytes

This a model from the article:
Electrophysiological modeling of fibroblasts and their interaction with myocytes.

Sachse FB, Moreno AP, Abildskov JA. Ann Biomed Eng.
year volume page 17999190
,
Abstract:

Experimental studies have shown that cardiac fibroblasts are electrically inexcitable, but can contribute to electrophysiology of myocardium in various manners. The aim of this computational study was to give insights in the electrophysiological role of fibroblasts and their interaction with myocytes. We developed a mathematical model of fibroblasts based on data from whole-cell patch clamp and polymerase chain reaction (PCR) studies. The fibroblast model was applied together with models of ventricular myocytes to assess effects of heterogeneous intercellular electrical coupling. We investigated the modulation of action potentials of a single myocyte varying the number of coupled fibroblasts and intercellular resistance. Coupling to fibroblasts had only a minor impact on the myocyte's resting and peak transmembrane voltage, but led to significant changes of action potential duration and upstroke velocity. We examined the impact of fibroblasts on conduction in one-dimensional strands of myocytes. Coupled fibroblasts reduced conduction and upstroke velocity. We studied electrical bridging between ventricular myocytes via fibroblast insets for various coupling resistors. The simulations showed significant conduction delays up to 20.3 ms. In summary, the simulations support strongly the hypothesis that coupling of fibroblasts to myocytes modulates electrophysiology of cardiac cells and tissues.
This model was taken from the CellML repository
and automatically converted to SBML.
The original model was:
sachse, moreno, abildskov.(2008) - version05

The original CellML model was created by:
Lloyd, Catherine, May

[e-mail]
The University of Auckland
Auckland Bioengineering Institute
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