Jak1 with compound 23
收藏Protein Data Bank Japan2024-10-23 更新2026-03-21 收录
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https://pdbj.org/mine/summary/6dbn
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Jak1 with compound 23 Descriptor: Tyrosine-protein kinase JAK1, [(1S)-2,2-difluorocyclopropyl][(1R,5S)-3-{2-[(1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl}-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone Authors: Vajdos, F.F. Deposit date: 2018-05-03 Release date: 2018-08-29 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.48 Å) Cite: Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841). J. Med. Chem., 61, 2018
创建时间：
2018-05-03
