Pathologically expanded peripheral B cell-helper T cells in rheumatoid arthritis
收藏NIAID Data Ecosystem2026-05-17 收录
下载链接：
https://www.ncbi.nlm.nih.gov/sra/SRP096372
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资源简介：
"PROSET-HD aims to identify and study immune cell populations altered in patients with autoimmune and inflammatory diseases. We have identified a population of PD-1hi CXCR5- ''peripheral helper'' T (Tph) cells that are expanded in the joints and circulation of patients with seropositive rheumatoid arthritis. This T cell population uniquely combines potent B cell-helper function with a migratory program that directs homing to inflamed tissues. RNA sequencing was performed on sorted memory CD4+ T cell subpopulations to compare the global gene expression profiles of PD-1hi CXCR5- CD4+ T cells, PD-1hi CXCR5+ follicular helper T cells, and other T cell populations obtained from blood of rheumatoid arthritis patients."
创建时间：
2017-09-17
