Revealing the Pathogenesis of Keloids Based on the Status: Active vs Inactive

Multiomics analysis demonstrated the distinct expression profile of active and inactive keloids. Clinically, these findings may provide the future appropriate directions for treatment of keloids depending on their activity and characteristics. Overall design: We aimed to profile the transcriptomics of FBs and vascular endothelial cells (VECs) of keloids according to their clinical activity and location within the keloid lesion. Tissue samples were collected (keloid based on its activity (active and inactive), mature scar (MS) from keloid patients and normal scar (NS) from non-keloid patients). Multiomics assessment was performed by using single-cell RNA sequencing and multiplex immunofluorescence. Increased mesenchymal FBs was the main feature in keloid patients.