CircTLCD4-RWDD3 promotes lymphatic metastasis in non-small cell lung cancer

Lung cancer is the leading cause of cancer-related death worldwide, and non-small cell lung cancer (NSCLC) accounts for approximately 85% of lung cancers. Lymphatic metastasis serves as a predominant NSCLC metastatic route and an essential predictor of patient prognosis. Recently, circular RNA (circRNA) has emerged as critical mediator in various tumor initiation and progression. To identify essential circRNA that involves in the lymphatic metastasis of NSCLC, Next generation sequencing (NSG) was performed in 6 paired NSCLC tissues and normal adjacent tissues (NAT). Overall design: To identify essential circRNA that is involved in the lymphatic metastasis of NSCLC, next generation sequencing (NSG) was performed in 6 paired NSCLC tissues and normal adjacent tissues (NAT).