Additional file 3: of Humanized yeast genetic interaction mapping predicts synthetic lethal interactions of FBXW7 in breast cancer

Table S2. HYGIN network table. This table contains the initial mapping data from the yeast network where SL interactions are represented in pairs by A and B (Yeast Gene ID A, Yeast Gene ID B, Yeast Gene Name A, Yeast Gene Name B, E-value, and P-value). Through the 3-stage mapping process used to generate HYGIN, it also contains columns corresponding to Yeast Protein Accession (A and B), Human Protein Accession (A and B), and Human Gene Name (A and B). Human gene names were used to generate the network in Cytoscape. Due to some reciprocal screens in the initial yeast screen, there were some duplicate (reciprocal) entries in this table. Once the network was loaded into Cytoscape, â Remove duplicate edgesâ was used to eliminate reciprocal hits. This resulted in the 1,009 genes and 10,419 edges in the final HYGIN network. (XLS 2700 kb)