Global genomic profiling of HIF-1a-regulated genes in bone marrow B cells under hypoxia or normoxia

HIF-1a works as a stress-induced transcription factor to induce target genes mediating cell proliferation, meabolism and inflammation. To gain new insights into HIF-1a biology, we used high-throughput sequencing to analyze global HIF-1a transcriptional networks in WT or HIF-1a deficient bone marrow B cells under hypoxia or normoxia. Overall design: RNA-seq was used to define HIF-1a regulated genes in bone marrow B cells from WT and HIF-1a deficient mice.