Single-cell analysis of conventional dendritic cells in an immunogenic murine melanoma model

Single-cell RNA sequencing was used to show the heterogeneity of conventional dendritic cells in the immunigenic murine melanoma BRAFV600E Ptgs1/Ptgs2-/-. Our analysis shows that on day 6 of tumor growth, 3 distinct populations of cDC1 and 2 distinct populations of cDC2 can be found in the tumor microenvironment. The differentially expressed genes of these populations indicate a functional heterogeneity. Analysis of heterogeneity of the conventional dendritic cell population within an immunogenic murine melanoma model.